Cameron grew up around a plank road that was followed in later years by a railroad. The town was planned in 1875 and incorporated in 1876. Cameron was at the end of the Raleigh and Augusta Railroad. Its location made it an ideal place of entrepreneurs to establish businesses. They built turpentine distilleries, established mercantile and hotel businesses to serve the needs of the railroad's customers and built a thriving dewberry farming and consignment operation.